Yes... but, you'll have to be much smarter than whatever gameplay is trying deploy as obstacles to keep going.
Fairly simple in fact; You can't win if you don't reach any of the Victory conditions.
74.5% Influence, at war with the *last* AI opponent, being ahead enough in the tech race that it can't beat you to that victory status, etc.
Nobody needs a modder to reproduce such situations, all they require is the proper skill to enforce such context.
