OK this may seem simple minded but that's because I'm simple minded. To set up a galaxy, instead of vague terms about "the size of this" or "far apartness" etc. why not
1. Set the number of sectors
2. Set the approximate number of civs per sector.
3. Set the total number of civs. With a fairly narrow window of acceptable combos.
Done.
Of course the numbers will have to align so that it makes sense - and you won't be able to select impossible combinations, like 1 civ per sector, 10 sectors and 30 total civs. The player will have to adjust things until the numbers work, but it won't be hard. In this example you would rarely get 3 civs in a sector or zero, but mostly 1 or 2.
Small variation is allowed on a random basis, but I can suggest as an example, say, 1.5 civs per sector with 10 sectors, and a total number of civs. Say in this example, 15 total civs. That's the way I have thought about it but the mechanism actually provided is as I say rather vague and generally doesn't give me what I hoped for.
My further comment is that this seems rather trivial superficially but it actually has a ton of importance for a player getting the right "feel" to the game. (How much exploration do you want? How soon you will bump into other civs? etc.)
My 2c.