Stardock, GC2 was very moddable and I wanted to make it clear that I (and probably others) hope that we'll have the same again this time around. I don't mind if I have to mess around with XML or other files, I don't need a GUI for my modding work. Personally, I don't mind if mods don't work on Multiplayer (though I'd prefer a central hub system where mods could be downloaded and synced - in game - for all players of a game).
I remember there were a couple of "special snowflakes" last time around, namely troop/colony modules and the Xeno Ethics event, which couldn't be replicated by modders. I'd really love to avoid a similar hangup with GalCiv III.
Also, it may be a pipe dream, but I'd love some scripting this time around!