I hope anyway. (WinXP) The only running issue I've had is background music popping and breakup when I would go into the Civ Manager and view the Timeline screen. It started with just pops but if I stayed there long enough the sound would breakup and then affect the sounds to the point it would not recover when I left the screen and affect all sounds afterwards. The only thing I could do was save and restart.
I read posts here that said to turn down "Hardware Acceleration" a notch from the sound properties. What I also found is you can change the "Sample rate conversion quality" and also resolve the issue.
The difference in quality to my old ears is negligible .
Go to Control Panel/Sounds and Audio Devices/Click Advanced under Speaker settings/Click Performance Tab/Move the Sample rate conversion quality slider to the middle/Apply and OK your way out.
I don't know how much this will help others since computers vary so much but mine is a bit over the recommended requirements and it works.
Again Brad thanks for ANOTHER great game.